Labor Pain
Conditions
Keywords
labor, pain, oxycodone, placenta
Brief summary
Oxycodone is used to treat pain in early labor, however the effect of oxycodone to placental or fetal circulation has not been evaluated. Oxycodone is increasingly used to treat labor pain in the early phase. The aim of the randomised, double blinded, placebo controlled study was to evaluate the effects of oxycodone in placental circulation, efficacy and safety of oxycodone and the effects to the newborn.
Interventions
DRUGOxycodone
The patients are given at first oxycodone 0,05 mg/kg and after one hour oxycodone 0,05 mg/kg if their pain in numerical rating scale from 0 to 10 is 5 or more
DRUGPlacebo
The patients are given at first placebo and after one hour oxycodone 0,05 mg/kg if their pain in numerical rating scale from 0 to 10 is 5 or more
Sponsors
Admescope Ltd
Kuopio University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* oxycodone planned for pain relief * age 18 years or more * Informed consent obtained * Full term pregnancy
Exclusion criteria
* No oxycodone planned * age less than 18 years * No informed consent * not full term pregnancy * Other contraindication to oxycodone
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| placental blood flow | from zero hours to two hours after the first study drug | Placental blood flow is measured with doppler ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| uterine arterial flow | from zero hours to two hours after the first study drug | uterine arterial flow is measured with doppler ultrasound |
Countries
Finland
Outcome results
None listed