Optical Coherence Tomography and Optic Neuritis (OCTON)

Optical Coherence Tomography for the Etiological Diagnosis of Inflammatory Optic Neuritis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02573792

Acronym

OCTON

Enrollment

120

Registered

2015-10-12

Start date

2015-10-05

Completion date

2019-07-31

Last updated

2021-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optical Neuritis

Keywords

First onset of optical neuritis

Brief summary

Optic neuritis (ON) can remain isolated or reveal a widespread and chronic disease of the central nervous system (CNS), a multiple sclerosis (MS) or, more rarely, a Devic's neuromyelitis optica (NMO) or a systemic disease. The optical coherence tomography (OCT) is a retinal imaging technique to measure the thickness of the retina and its different layers with an accuracy of 4-6 µM. Costello et al have shown that approximately 75% of 54 MS patients have developed within 3 to 6 months after a ON a loss of 10 to 40 µM in the thickness of the peripapillary retinal nerve fiber layer (RNFL). The etiologic diagnosis of ON has been transformed in recent years. MS can now be diagnosed by McDonald's MRI criteria and NMO by the AQP4 antibodies (anti-aquaporin- 4) antibodies and the anti-MOG (myelin-oligodendrocyte glycoprotein) antibodies. The diagnosis and prognosis value of the OCT in patients with ON is not well known

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* first onset of an optical neuritis lasting for less than 3 months

Exclusion criteria

* Contra-indication to MRI * Patient opposed to participation in the study * Pregnant or lactating woman * Patient under a measure of legal protection * Absence of affiliation to social security or universal health coverage (CMU)

Design outcomes

Primary

Measure	Time frame
Sensitivity of the OCT, expressed as a percentage, for the etiological diagnosis of optical neuritis	One year

Countries

France

Outcome results