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KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer

KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02573441
Enrollment
28
Registered
2015-10-09
Start date
2015-10-31
Completion date
2018-05-31
Last updated
2025-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Brain Tumor

Brief summary

The study will examine whether school liaison services and home-based parental tutoring can help with academic difficulties of paediatric brain tumour survivors who received cranial spinal radiation and have returned to school. Forty-five patients will participate in the project. All patients will receive psychology liaison services to link resources at the hospital with those in the community. Patients will participate in one of two tutoring programs designed to directly or indirectly improve math skills over 12 weeks. Weekly phone calls will be used to support parents using the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities.

Detailed description

Paediatric brain tumour survivors who receive cranial spinal radiation have learning problems, particularly in mathematics and working memory. Working memory is often described as a mental workspace where relevant information is held in mind and processed. Working memory is important in mathematics for holding in mind relevant information and carrying out steps necessary to solve problems. This study will examine whether school liaison support and home-based parental tutoring can help address the academic difficulties of paediatric brain tumour survivors who have received cranial spinal radiation and who have returned to their community school. Forty five patients will participate in the project. First, all patients will receive psychology liaison services to link resources at the hospital with those in the community in order to provide information regarding the effects of pediatric cancer on learning and facilitate the implementation of appropriate assistive technology and remediation programs. Patients will then participant in one of two tutoring programs over the course of a 12 week period. One group of patients will participate in a program that addresses working memory with the intent of indirectly helping with mathematics skills. This program will be delivered over the internet. Another group of patients will participate in a program using a work book to directly help improve mathematics skills. Weekly phone calls will be used to support parents in doing the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities. The two intervention programs will be compared to a waitlist control group that receives only the liaison service (including academic support through weekly phone calls over the 12 weeks). The findings from this study will provide evidence about the type of intervention that is most effective at helping paediatric brain tumour survivors improve their mathematics skills and working memory ability.

Interventions

BEHAVIORALJump Math

Jump Math is a workbook based program aimed at improving math skills

BEHAVIORALCogmed

Cogmed is an online computer program aimed at improving working memory skills

BEHAVIORALLiaison Services

Liaison Services will include working closely with schools to help explain the strengths and weaknesses of a child based on cognitive testing and to help with the implementation of recommendations

Sponsors

Pediatric Oncology Group of Ontario
CollaboratorOTHER
The Hospital for Sick Children
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
6 Years to 17 Years
Healthy volunteers
No

Inclusion criteria

* Has been diagnosed with a brain tumour and treated with cranial radiation * Is between 1 and 10 years following diagnosis * Has English as his or her native language or has had at least two years of schooling in English * Is between the ages of 6 and 17 * Less than a Grade 8 equivalent math score

Exclusion criteria

* Is younger than 6 years or older than 17 years of age * Is receiving palliative care

Design outcomes

Primary

MeasureTime frameDescription
Monitoring Basic Skills ProgressPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of mathematics
Woodcock Johnson Academic-Third EditionPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of math Fluency, applied math problems, and qualitative concepts
Wechsler Intelligence Scale for Children - Fourth Edition IntegratedPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of verbal and visual working memory
Wide Range Assessment of Memory and Learning - Second EditionPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of verbal and visual working memory
Automated Working Memory AssessmentPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of verbal and visual working memory
Connors' Continuous Performance Test-Second EditionPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of sustained attention
Behaviour Rating Inventory of Executive Function-Parent VersionPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of executive functioning

Secondary

MeasureTime frameDescription
Wide Range Assessment of Memory and Learning - Second EditionPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of visual learning and memory
California Verbal Learning Test, Children's VersionPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of verbal learning and memory
CANTABPre-intervention, 12 weeks after intervention and 6 months follow-upMeasures of processing speed
Wechsler Abbreviated Scale of Intelligence - Second EditionPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of vocabulary and abstract visual reasoning
Delis-Kaplan Executive Function SystemPre-intervention, 12 weeks after intervention and 6 months follow-upMeasures of processing speed and switching attention
SAMPre-intervention, 12 weeks after intervention and 6 months follow-upA measure of participants attitude towards math

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026