The Lean Meats Mediterranean Diet Study

Conditions

Cardiovascular Diseases, Dietary Modification

Keywords

cardiovascular disease risk, Mediterranean diet, red meat

Brief summary

The purpose of the proposed research study is to assess the effects of including greater amounts of minimally processed red meat (lean pork and beef) into a Mediterranean Diet on cardiometabolic and emotional well-being.

Detailed description

All subjects will complete an 18-wk randomized crossover study. Following a 2-wk baseline testing period to assess cardiometabolic and emotional well-being and habitual diet, subjects will consume a Mediterranean-style, weight-maintenance diet that is either restricted or rich in lean, minimally processed red meat for 5 weeks. Following a 4-wk washout period and second 2-wk baseline testing, subjects will consume the Mediterranean Diet with the alternate predominant animal protein sources for 5 weeks. Cardiometabolic and emotional well-being will be assessed during baseline and post periods.

Hill EB, Reisdorph RM, Rasolofomanana-Rajery S, Michel C, Khajeh-Sharafabadi M, Doenges KA, Weaver N, Quinn K, Sutliff AK, Tang M, Borengasser SJ, Frank DN, O'Connor LE, Campbell WW, Krebs NF, Hendricks AE, Reisdorph NA.

2023-10-314 citations

10.1016/j.tjnut.2023.10.024

A Mediterranean-style Eating Pattern Lower in Lean Red Meat Reduced Plasma Trimethylamine N-Oxide in Adults Classified as Overweight or Obese (P08-030-19)

Erik Gertz, Yu Wang, Lauren E O’Connor, W. W. Campbell, Brian J. Bennett

Current Developments in Nutrition2019-06-01

10.1093/cdn/nzz044.p08-030-19

Adopting a Mediterranean-Style Eating Pattern with Different Amounts of Lean Unprocessed Red Meat Does Not Influence Short-Term Subjective Personal Well-Being in Adults with Overweight or Obesity

Lauren E O’Connor, Sarah L Biberstine, Douglas Paddon‐Jones, A. J. Schwichtenberg, W. W. Campbell

Journal of Nutrition2018-08-2315 citations

10.1093/jn/nxy235

A Mediterranean-style eating pattern with lean, unprocessed red meat has cardiometabolic benefits for adults who are overweight or obese in a randomized, crossover, controlled feeding trial.

O'Connor LE, Paddon-Jones D, Wright AJ, Campbell WW.

2018-07-0156 citations

10.1093/ajcn/nqy075

Interventions

OTHERRed Meat Restricted

restrict intake of red meat while a Mediterranean diet

OTHERRed Meat Rich

Mediterranean diet rich in red meat

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 69 Years

Healthy volunteers

Yes

Inclusion criteria

* Male or female 30-69 years old * BMI 25-37 kg/m2 * Total cholesterol \<240 mg/dL * Low-density lipoprotein \<160 mg/dL * Triglycerides \<400 mg/dL * Fasting glucose \<110 mg/dL * Systolic blood pressure \<160 mmHg * Diastolic blood pressure \<100 mmHg * Body weight \<300 lb * Weight stable for 3 months prior (±10 lb) * Stable physical activity regimen 3 months prior ≤3 h/wk of moderate or high intensity exercise resistance or aerobic training * Medication use stable for 6 months prior.

Exclusion criteria

* Diabetic * Smoker

Design outcomes

Primary

Measure	Time frame	Description
blood pressure	5 weeks	clinical and 24-hr monitoring
lipid profile	5 weeks	cholesterol panel

Secondary

Measure	Time frame	Description
sleep quality	5 weeks	sleep assessed by using actigraphy / actiwatch
sleep assessment	5 wks	Sleep assessed by questionnaires using the Pittsburgh Sleep Quality Index
assessment of sleep	5 weeks	Sleep assessed by questionnaires using the SF-36v2® Health Survey
emotional well-being	5 weeks	quality of life questionnaires

Countries

United States

Outcome results

None listed