Cardiovascular Disease in Obstructive Sleep Apnea
Conditions
Keywords
obstructive sleep apnea, endothelial dysfunction, periodontitis
Brief summary
Evaluation of the add-on effect on endothelial dysfunction of treatment of periodontitis in patients with chronic periodontitis and severe obstructive sleep apnea treated by CPAP. Patients with and without chronic periodontitis will be treated by CPAP for 20 weeks. At V2 (10 weeks), endothelial dysfunction will be assessed by the Reactive Hyperemia- Peripheral Artery Tone index. The endothelial dysfunction of the patients will be also assessed at V3 (20 weeks) after periodontitis treatment for the group of patients with chronic periodontitis.
Detailed description
At V2, patients with periodontitis will have full-mouth intensive removal of denatl plaque biofilms with the use of scaling and root planing. The add-on effect of the periodontitis treatment on endothelial dysfunction will be assessed ten weeks later (V3) in comparison with V2 by taking into account with the effect of 10 weeks of CPAP in the control group with severe OSA but not periodontitis.
Interventions
PROCEDUREscaling and root planing
full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planing after the administration of local anesthesia
Sponsors
Hopital Foch
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* severe OSA defined by an apnea hypopnea index \> or = 30 per hour * with or without chronic parodontitis
Exclusion criteria
* non equilibrated diabetes * obesity (BMI \> or = 40) * active smoker (\> 1 pack per day (20 cigarettes)) * pregnancy * antibiotics within the preceding three months * prophylactic antibiotherapy required for the parodontitis treatment * acute parodontitis or all parontal pathology requiring immediate therapy * less than 10 teeth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial function | 20 weeks | measure of Reactive Hyperemia- Peripheral Artery Tone index with Endopat |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial function | 10 weeks | measure of Reactive Hyperemia- Peripheral Artery Tone index with Endopat |
| blood biomarkers | 0, 10 and 20 weeks | hsCRP, leptin, adiponectin, E-selectin and orosomucoid |
| Epworth Sleepiness Scale | 0, 10 and 20 weeks | — |
Countries
France
Outcome results
None listed