Neoplasms, Second Primary
Conditions
Brief summary
Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.
Detailed description
A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.
Interventions
No Intervention in this retrospective Analysis. All patients included did receive Radiation therapy Independent of this study
Sponsors
Klinik Hirslanden, Zurich
Kantonsspital Graubuenden
Study design
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Male/Female \> 18 years of age * pre or postoperative radiation therapy for rectal cancer * Planning CT
Exclusion criteria
* Planning CT not available
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Calculation of the organ-specific excess lifetime attributable risk (LAR) (%) | 60 years (model-based calculation) | LAR is calculated for variable Ages at exposure |
Countries
Switzerland
Outcome results
None listed