Active tDCS, Sham tDCS
Conditions
Keywords
neurostimulation, comorbidity, tDCS, CBT, anxiety, alcohol
Brief summary
The current study aims to examine the safety and feasibility of utilizing tDCS to enhance affect-laden episodic memory consolidation among adults with co-occurring alcohol use and anxiety disorders who have recently undergone detoxification as a step toward the translational clinical application of this approach.
Interventions
DEVICEActive tDCS stimulation
DEVICESham tDCS stimulation
Sponsors
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* DSM IV diagnosis of panic disorder (with or without agoraphobia), generalized anxiety disorder, or social anxiety disorder within the past 30 days * DSM IV diagnosis of alcohol dependence within the last 30 days * inpatient treatment at Lodging Plus primarily for alcohol (vs. other drug) dependence * alcohol use in the 30 days preceding the study * willingness to provide informed consent * minimum of a sixth grade English reading level (deemed necessary to complete study materials); as determined by their being able to read and understand the consent form. * Living within reasonable driving distance (1 hour or less) of the Twin Cities to allow for in-person follow-up interviews
Exclusion criteria
* lifetime history of psychosis or mania by history. * cognitive (e.g., dementia) or physical impairment (e.g., blindness) that interferes with study participation report or as judged by PI/study physician. * Current suicide risk as deemed by the PI and study physician to be serious and ongoing * any medical condition or treatment with neurological sequelae (e.g., stroke, tumor, loss of consciousness of more than 30 minutes, HIV, seizures) * history of ECT * document loss of consciousness (LOC) for longer than 30 minutes or LOC with neurological sequelae * pregnancy * Although seizures are not a known risk of tDCS intervention (Fregni et al., 2006; Nitsche et al., 2008), anyone with a history or a risk for seizures will be excluded from the study * anyone with metal objects implanted in their head or neck * anyone taking stimulant medications for any reason as we wish to avoid two sorces of neurostimulation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Therapy Content Memory Assessment | 24 hours | Participant's will complete daily assessments of their memory for therapy content from the previous session. |
Outcome results
None listed