Pain, Postoperative Period
Conditions
Keywords
Thoracotomy, Postoperative pain, Ketamine
Brief summary
Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.
Interventions
OTHERNSS
NSS infusion
DRUGKetamine
Ketamine 0.2 mg/kg/hr intravenous infusion
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* ASA physical status 1-3 * elective thoracotomy * can operate patient-controlled analgesia (PCA) machine
Exclusion criteria
patient with history of * allergy to morphine or ketamine * contraindicate to ketamine * remain intubated in the postoperative period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to first trigger of morphine | 24 hours | Time to first trigger of morphine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 24-hr morphine consumption | 24 hours | 24-hr morphine consumption |
| NRS score at 6, 24 hours | 24 hours | NRS score (0-10) was assessed at at 6, 24 hours postoperative |
| Incidence of nausea and vomiting | 24 hours | Incidence of nausea and vomiting |
Countries
Thailand
Outcome results
None listed