Effects of Prebiotics on GLP-1 in Type 2 Diabetes

Conditions

Diabetes Type 2

Brief summary

The aim of the study is to compare the effects of prebiotics versus placebo on blood concentrations of glucagon-like peptide-1 in subjects with diabetes type 2.

Detailed description

We looked at 6 weeks supplementation with a prebiotic fibre mix of inulin and FOS. Cross over design compared to maltodextrin as placebo. Additional outcome measures: blood glucose, insulin, GLP-2, ghrelin, PYY and leptin after a standardized mixed meal test. Also measured changes in microbiota composition and SCFA in feces before and after intervention/placebo periods, and subjective measures of appetite.

Eline Birkeland, Wuraola Aduke Bamigbetan, Kristine Duus Molven, Per Medbøe Thorsby, Hanne Løvdal Gulseth et al. (7 authors)

Archives of Osteoporosis2025-06-05

10.1007/s11657-025-01556-x

Effects of prebiotics on postprandial GLP‐1, GLP‐2 and glucose regulation in patients with type 2 diabetes: A randomised, double‐blind, placebo‐controlled crossover trial

Eline Birkeland, Sedegheh Gharagozlian, Hanne Løvdal Gulseth, Kåre I. Birkeland, Bolette Hartmann et al. (8 authors)

Diabetic Medicine2021-07-2322 citations

10.1111/dme.14657

Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial.

Birkeland E, Gharagozlian S, Birkeland KI, Valeur J, Måge I, Rud I, Aas AM.

2020-05-21138 citations

10.1007/s00394-020-02282-5

Interventions

DIETARY_SUPPLEMENTPrebiotic fibers: oligofructose and inulin

DIETARY_SUPPLEMENTMaltodextrin

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* diabetes type 2 * BMI 18,5 - 40 * Not medicated with insulin, GLP-1 analogues or DPP4 inhibitors * Moderate intake of alcohol * Not excessive exercise * Less than 3 kg weight change the last two months * Intake of less than 30 g dietary fiber per day

Exclusion criteria

* IBD * IBS * Coeliac disease * Have used antibiotics within the last two months * Have used supplements with prebiotics or probiotics the last two months * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Changes in plasma GLP-1 in response to standardized test meal before and after six weeks of ingestion of prebiotic fibers or placebo	six weeks	The changes in GLP-1 response to either prebiotic fibers or placebo will be compared in a cross-over manner where the participants are their own controls. In between the intervention periods there will be a wash-out period of 4 weeks.

Countries

Norway

Outcome results

None listed