Cardiovascular Disease
Conditions
Keywords
Weaning TTE, patients in prolonged weaning
Brief summary
The aim of the present study is to determine the cardiovascular function/ cardio respiratory interaction on spontaneous breathing trials in patients with prolonged weaning.
Interventions
OTHERSpontaneous breathing trial
Sponsors
RWTH Aachen University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* legal Age (≥18 years) * written informed consent Prior to study participation * patient in prolonged weaning with NYHA I-II and an actual positive Ventilator Screening test: 1. PaO2 ≥ 60 mmHg at FiO2 ≤ 0.4 2. PEEP ≤ 8 cmH2O 3. Glasgow Coma Scale \> 13 4. Temp. \< 38°C 5. Hb \> 80-100 g/L 6. less requirement on catecholamines (\<0.1µg/kg/min) * and on these patients are already performed a spontaneous breathing trial with following result: 1. abortion this spontaneous breathing trial \< 30min, but possible \> 10min 2. reason for an abortion was NOT hypercapnia
Exclusion criteria
* weaning patients are assigned on Group 1-2 * patient with heart failure (NYHA III-IV) and/ or other cardiac comorbidity * acute NSTEMI (non-ST-segment elevation myocardial infarction) * pregnancy and breast-feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Baseline measurement (Modus CPAP-PS) in patient with prolonged weaning | 12 months | under pressure support Ventilation are determined some measurement (e.g. breathing rate) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intervention measurement in patient with prolonged weaning | 12 months | 20 min breathing without mechanical ventilation |
Countries
Germany
Contacts
Primary ContactMichael Dreher, MD
Outcome results
None listed