Pain, Postoperative
Conditions
Keywords
Dexketoprofen, Etoricoxib, hip arthroplasty, pain
Brief summary
The main purpose of this study was to determine the plasma and central nervious system pharmacokinetics of dexketoprofen and etoricoxib. The secondary aim was to asses their effect on the concentrations of interleukin 6, prostaglandin E2 and other proinflammatory markers both in plasma and cerebrospinal fluid. Thirdly, the investigators aimed to evaluate their efficacy in postoperative pain treatment.
Interventions
DRUGDexketoprofen
After total hip replacement surgery patient were given either etoricoxib or dexketoprofen
DRUGEtoricoxib
After total hip replacement surgery patient were given either etoricoxib or dexketoprofen
Sponsors
Kuopio University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* agreed to participate the study * American Society of Anesthesiologist s physical status classification 1-3 * elective hip arthroplasty planned * no contraindications to the study drugs * no contraindication to lumbar puncture
Exclusion criteria
* refused to participate the study * age less than 40 or over 75 years * Planned anesthesia method other than spinal anesthesia * contraindications to the study drugs * Contraindications to lumbar puncture
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebrospinal fluid concentration dexketoprofen and etoricoxib | 0-24 hours | Cerebrospinal fluid concentration of dexketoprofen and etoricoxib |
| Plasma concentration dexketoprofen and etoricoxib | 0-24 hours | Plasma concentration dexketoprofen and etoricoxib |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain | 0-24 h | Pain assessed with numeral rating scale |
Outcome results
None listed