Breast Cancer
Conditions
Brief summary
Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence. The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.
Detailed description
The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order. 1. immediate before anesthesia induction 2. postoperative 1 hours 3. postoperative 24 hours Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay
Interventions
DRUGpropofol group
Patient will be anesthetized by using propofol infusion during operation.
Patient will be anesthetized by using sevoflurane inhalation during operation.
Sponsors
Konkuk University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient who was planned to undergo colon cancer surgery.
Exclusion criteria
* age \< 20 years old * history of hypersensitivity reaction in propofol or sevoflurane * history of previous cancer * patient with ongoing inflammation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CD39 and CD73 on circulating regualtory T cells | preoperative time. postoperative 1 hours and 24 hours | change of percentage of CD39 and CD73 (scores range from 0 to 100) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Circulating natural killer cells | preoperative time. postoperative 1 hours and 24 hours | change of percentage of circulating natural killer cell (scores range from 0 to 100) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Circulating type 1 and type 17 helper T cells | preoperative time. postoperative 1 hours and 24 hours | change of percentage of helper T cell (scores range from 0 to 100) |
Countries
South Korea
Outcome results
None listed