Motor Activity
Conditions
Keywords
pre liver transplantation patients
Brief summary
Physical exercise has been identified as a major beneficial factor in the management of patients suffering from many chronic diseases especially cancer and in the context of cardiac or pulmonary transplantation. It contributes to an improvement of the quality of life and decreases treatment side effects and mortality. Aerobic fitness is constantly altered in cirrhotic patients and correlated to the severity of the hepatic disease. Moreover, in this setting, other etiological factors may be added like chronic obstructive bronchitis and alcoholic cardiomyopathy. In this population, muscle abnormalities with fatigue and cramps have been described. Muscle weakness in this condition may be comparable to that described in patients with chronic obstructive bronchitis and contributes to the decrease of aerobic fitness. Different causes such as muscle deconditioning, hypoxemia, denutrition, anti-rejection drugs increase this phenomenon after liver transplantation. Finally, the aerobic capacity or VO2max is a prognostic factor for survival and is linked to the number and the length of hospitalizations after liver transplantation (LT). Therefore, physical activity is a valid and relevant way to improve quality of life, increase survival, and limit costs of hospitalizations. The aim of this study is to assess the effects of a personalized physical activity retraining program on aerobic capacity, strength and fatigue, in a population awaiting liver transplantation. Purpose: The hypothesis is that an at home adapted retraining program conducted before LT, and including physical activity (aerobic and strength training), will improve aerobic fitness, peripheral strength, quality of life and decrease the hospitalization length in intensive care unit after LT.
Interventions
OTHERPhysical activity
walk (three times per week) and muscle building twice per week with the use of elastic bands. They will include 5 strengthening exercises mobilizing large muscle groups of the lower limbs (abs (if possible for the patient), hamstrings, quadriceps, triceps sural and gluteus maximus).
Sponsors
University Hospital, Limoges
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Males and females between 18 and 70 years of age, * Signed informed consent, * Medical indication to LT whatever the cause of the liver disease
Exclusion criteria
* Inability to understand the instructions of the trial, * Patients who are subject to a court protection, wardship or guardianship order, * Uncontrolled cardiac disease and ventricular ejection fraction (vef) \< 50 %, * Any other serious conditions which are not stabilized and in which physical exercise is contra-indicated, * Pregnancy or suckling, * Patients transplanted in extreme emergency.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VO2 max at 12 weeks | at 12 weeks | To evaluate the impact of a personalized physical activity program after 12 weeks of exercise on the aerobic capacity measured by VO2 max, in patients awaiting liver transplantation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 6 minutes walk test at week 12 | at 12 weeks | To evaluate at Week 12: 6 minutes walk test |
| After liver transplantation: aerobic capacity (VO2 max) | 3 and 6 months after liver transplantation | To evaluate after liver transplantation: aerobic capacity (VO2 max) 3 and 6 months after LT |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORMarilyne DEBETTE-GRATIEN
University Hospital, Limoges
Outcome results
None listed