Implants
Conditions
Brief summary
The investigators aim to determine the cause of failure of orthopaedic implants using multi-disciplinary analysis of data from patients who have undergone revision.
Detailed description
The following tests will then be arranged: * Tribological assessment. The investigators will measure the wear of the explants using: 1) 'out of roundness'; and 2) Coordinate measuring. Semi-quantitative assessment of damage to the explants will also be conducted * Histological assessment. Tissue sent in formalin may determine the biomarker of diagnosis of metal ion synovitis where applicable * Metal ion measurement in body fluids where applicable (in patients with metal implants) * Diamond Light Source (this was approved in the 1st amendment). The tests will involve subjecting formalin fixed tissue to the high energy electron beam of the Diamond Light Source * Destructive testing of the implant is allowed by the patient (after all non-destructive tests have been performed) * Protein analysis of fluid and tissue if provided * Titanium levels from blood samples if provided * Gene expression testing to assess and understand mechanism of inflammation where applicable
Interventions
PROCEDUREImplant
orthopaedic implant
Sponsors
Massachusetts General Hospital
Coxa, Hospital for Joint Replacement
Royal National Orthopaedic Hospital NHS Trust
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
11 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* All patients undergoing revision of an orthopaedic implant (previously this was limited to metal hips but this has now expanded to other orthopaedic implants)
Exclusion criteria
* Patients not consenting to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cause of failure | At time of failure which is likely to be an average of 5 years post operative |
Countries
United Kingdom
Contacts
Primary ContactIva Hauptmannova, BSc
Outcome results
None listed