Irritable Bowel Syndrome
Conditions
Keywords
microbiota community, IBS
Brief summary
Analyze microbiota community of irritable bowel syndrome in episodes phase and remission phase.
Detailed description
The pathophysiology of IBS is incompletely understood, it may involve an altered intestinal microbiota. Since the microflora composition of IBS is various in different studies, The investigators plan to compare the intestinal microbiota of IBS patients in episodes phase and remission phase with healthy controls,trying to find the difference.
Interventions
OTHERcollect faeces from participants
analyze the fecal microbiota community using 16S rDNA detection technique
Sponsors
Shandong University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* the presence of Rome III criteria for IBS ; * Patients scheduled for colonoscopy examination or having negative screening examinations * Aged between 18 and 65 years old
Exclusion criteria
* Antibiotic, probiotic or laxative usage within 4 weeks. * organic gastrointestinal diseases * Severe systematic disease: diabetes mellitus, hepatic, renal or cardiac dysfunction, thyroid disease or tumor etc. * pregnancy or lactation. * previous major or complicated abdominal surgery. * severe endometriosis and dementia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microbiota community among IBS patients in episodes phase,remission phase and healthy controls | 5 months |
Secondary
| Measure | Time frame |
|---|---|
| quality of life in IBS patients | 5 months |
Countries
China
Contacts
Primary ContactYanqing Li, MD.PhD
Outcome results
None listed