Cancer, Complications, Sequels
Conditions
Keywords
Childhood cancer, Cancer, Sequels, Surgery, Complications, Chemotherapy, Radiotherapy
Brief summary
Survival rate of childhood cancers is now reaching 80%. However, early or late complications related to surgery, chemotherapy and radiotherapy remain high and greatly increase the risk of late mortality. Health of individuals is closely correlated to the stability of the autonomic nervous system (ANS), a key system for maintaining homeostasis in any living species. Efficient computer tools allowed the opportunity to assess the intrinsic autonomic regulation of the ANS either directly or at a later time by an analysis of the heart rate variability (HRV). These tools have become very powerful predictors of cardiovascular morbidity and neurological aging. Physical endurance training improves both maximal aerobic capacity and ANS activity.
Detailed description
The main objective of this study is to evaluate improvement of ANS parameters after 6 months of adapted physical activity in adults treated for childhood cancer in Rhône-alpes region in France who have deregulation ANS or autonomic imbalance.
Interventions
OTHERAdapted physical activity
The adapted physical activity is done by Education Physique et Gymnastique Volontaire (EPGV) centres.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Included in the SALTO\_SNA study (NCT01574196) * Alteration of the autonomic nervous system activity or deregulation of the sympatho-vagal balance
Exclusion criteria
* Written consent form * Left ventricular dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Autonomic nervous system activity | At 6 months | The autonomic nervous system activity is classified in sympatho-vagal equilibrium as normal, altered or severely abnormal. For this classification, we need the values obtained for some temporal indices (Standard Deviation NN intervals (SDNN), Root Mean Square of Successive Differences (RMSSD)) and frequencies (Ptot, High Frequency (HF), Low Frequency (LF) , Very-Low Frequency (VLF), ratio LF / HF) compared to validated standards for the age (mean +/- standard deviation). |
Secondary
| Measure | Time frame |
|---|---|
| Daily activity questionnaire | At 6 months |
| Quality of Life Questionnaire | At 6 months |
Countries
France
Outcome results
None listed