Acute Urticaria
Conditions
Keywords
acute urticaria, glucocorticoids, antihistamines, prurit, itch score, rash
Brief summary
Acute urticaria is common and affected 12% of population. 400 patients come in department emergency of Toulouse each year and there aren't many studies in literature which evaluate the glucocorticoids treatment. The standard treatment of urticaria is antihistamines H1, but glucocorticoids treatment administered orally for short course would permit to increase quickly acute urticaria uncomplicated. Clinical trial, prospective randomized double blinded of adults with acute urticaria less 24 hours duration and no take treatment urticaria before.
Detailed description
Acute urticaria is common and affected 12% of population. 400 patients come in department emergency of Toulouse each year and there aren't many studies in literature which evaluate the glucocorticoids treatment. Acute urticaria is pruritic and incapacitating for daily life. The standard treatment of urticaria is antihistamines H1, but glucocorticoids treatment administered orally for short course would permit to increase quickly acute urticaria uncomplicated. Clinical trial, prospective randomized double blinded of adults with acute urticaria less 24 hours duration and no take treatment urticaria before. One group randomized received 40mg of cortancyl and 1 pill of citerizine and another group randomized received 1 pill citerizine and placebo like cortancyl. Pharmacy hospital takes care of randomization. Pruritus evaluated with icth score and rash evaluated with nine rule of Wallace, the patient is evaluated in T0, one hour after and contacted by telephone at J2, J5, J15, J 21 itch score, Wallace extension, observance, side effects are asked him.
Interventions
DRUGplacebo
Xyzall 5mg during 5 days + placebo 40mg during 4 days
DRUGprednisone
Xyzall 5mg during 5 days + prednisone 40mg during 4 days
Sponsors
University Hospital, Toulouse
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adults * urticaria rash no more 24 h duration and no take treatment for urticaria
Exclusion criteria
* patients were presented severe anaphylaxis or taken antihistamines or glucocorticoids within 5 days of arrival at ED, * severe infection * pregnancy * patients BPCO * diabetics * allergy corticosteroids * refusal to comply * participate an other study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare treatment with prednisone and antihistamines versus antihistamines placebo to out acute urticaria in 48 hours | 48 hours | To compare treatment with prednisone and antihistamines versus antihistamines placebo to out acute urticaria in 48 hours using the itch score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The frequency of side-effects in either treatment group in 21 days | 21 days | The frequency of side-effects in either treatment group in 21 days |
| Evolution of intensity pruritus, angioedema and rash with nine rule of Wallace | 21 days | Evolution of intensity pruritus at T0 and T1, J2, J5, J15, J21 and angioedema and rash at T1, J2, J5, J15 and J21 comparing at T0 with nine rule of Wallace |
| The necessary time to decrease pruritus and rash | 21 days | The necessary time to decrease pruritus and rash |
| Recidive of urticaria | 21 days | The recidive of urticaria |
| The observance treatment | 21 days | Observance treatment |
Countries
France
Outcome results
None listed