Hyporesponsiveness of Natural Killer Cells and a Dysfunctional Inflammatory Response in Critically Ill Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02565589

Enrollment

Registered

2015-10-01

Start date

2014-04-30

Completion date

2015-09-30

Last updated

2017-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness

Brief summary

To investigate natural killer (NK) cell activities, circulating cytokine levels and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients.

Detailed description

Blood samples were collected \< 24 hours after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. NK cell activities, cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* ICU patients * For healthy controls: nondiabetic and nonobese subjects

Exclusion criteria

* For healthy controls: diabetes; history/presence of significant metabolic disease; pregnancy or breast-feeding; acute or chronic infection; liver disease; kidney disease; gastrointestinal disease; subjects taking any drugs or supplements

Design outcomes

Primary

Measure	Time frame	Description
NK cell activity	Baseline	NK cell activity (%)

Secondary

Measure	Time frame	Description
IL (Interleukin)-12	Baseline	IL-12 (pg/mL)
hs-CRP (high-sensitivity C-reactive protein)	Baseline	hs-CRP (mg/dL)

Outcome results