Irritable Bowel Syndrome
Conditions
Keywords
Microbiota Community, FODMAPs, IBS
Brief summary
To determine the efficacy of a low FODMAP diet in IBS patients and whether gut microbiota community is associated with its efficacy.
Detailed description
We seek to determine whether a low FODMAPs diet decreases symptoms in irritable bowel syndrome (IBS)patients and to identify potential microbial factors related to diet efficacy. Pain symptoms, stooling characteristics, breath hydrogen, stool microbiome will be collected and/or documented in IBS patients at baseline and during one week of an low FODMAPs intervention.
Interventions
DIETARY_SUPPLEMENTlow FODMAPs
low FODMAPs means excluding food which contains oligosaccharides.disaccharides,monosaccharides, and polyols
Sponsors
Shandong University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* the presence of Rome III criteria for IBS ; * Patients scheduled for colonoscopy examination or having negative screening examinations * Aged between 18 and 65 years old
Exclusion criteria
* Antibiotic, probiotic or laxative usage within 4 weeks. * organic gastrointestinal diseases * Severe systematic disease: diabetes mellitus, hepatic, renal or cardiac dysfunction, thyroid disease or tumor etc. * pregnancy or lactation. * previous major or complicated abdominal surgery. * severe endometriosis and dementia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes of symptom scores | 5 months |
Secondary
| Measure | Time frame |
|---|---|
| proportion of responders | 3 months |
| quality of life in IBS patients | 5 months |
| microbial composition in different response to low FODMAPs | 5 months |
Countries
China
Contacts
Primary ContactYanqing Li, MD.PhD
Outcome results
None listed