Pregnancy
Conditions
Keywords
polyunsaturated fatty acid, fetal ductus arteriosus, inflammation
Brief summary
The effect of anti-inflammatory substances on the dynamics of the fetal ductus arteriosus is well documented, but the anti-inflammatory property of polyunsaturated fatty acid omega-3 about changing this dynamic is not established. This study evaluate the relationship between supplementation of omega-3 in the dynamics of the fetal ductus arteriosus in the third trimester. Women with gestational between 28 to 32 weeks will receive capsules of omega-3 or placebo, to be consumed daily for 3 weeks.
Detailed description
The omega-3 features similar the statins to be antioxidants and anti-inflammatory drugs and their derivatives have the function of slowing the neuro-inflammation, oxidative stress and apoptotic cell death anti-inflammatory properties. Also, they have antithrombotic effects, being related to prevent disease. Studies show that supplementation with omega-3 has a positive impact on several outcomes like cardiovascular disease, asthma, rheumatoid arthritis and Alzehimer. Objective: Evaluate the relationship between supplementation of omega-3 in the dynamics of the fetal ductus arteriosus in the third trimester. Methodology: randomized double blind clinical trial. Women with gestational age between 28 to 32 weeks, literate, over 18 years will be invited. Pregnant women with anti-inflammatory drugs, they have a higher intake of dietary polyphenols to 127mg / day or using drugs that may interfere with the absorption of omega-3 are excluded. The selected women will be randomized to receive capsules of omega-3 or placebo, to be consumed daily for 3 weeks. In the first interview, and after 3 weeks, they will respond the Questionnaire Food Frequency (QFF) to quantify polyphenols and omega 3 in their diet, weight and height will be measured and the examination of fetal echocardiography is performed.
Interventions
DIETARY_SUPPLEMENTOmega 3
Pregnant women should take 2 capsules of omega 3 (1g), 2 times a day, for 21 days.
DIETARY_SUPPLEMENTSoy Oil
Pregnant women should take 2 capsules of placebo 3 - soy oil oil (1g), 2 times a day, for 21 days.
Sponsors
Instituto de Cardiologia do Rio Grande do Sul
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Women between 28 - 32 weeks pregnancy who accept participate in the study. \-
Exclusion criteria
hypertensive , diabetic , who use anti-inflammatory drugs , HIV positive , do not take mate, black or green tea, had inflammation in the last 5 days, allergic to fish or soy. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulsatility index of fetal ductus arteriosus | 28 to 32 weeks of pregnancy | The measure will be collected before and after 21 days of supplementation with omega 3 capsules |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Systolic and diastolic velocity of fetal ductus arteriosus | 28 to 32 weeks of pregnancy | The measure will be collected before and after 21 days of supplementation with omega 3 |
| Inflammatory biomarkers (interleukins, prostaglandins, cyclooxygenase) | 28 to 32 weeks of pregnancy | Will be collected blood before and after 21 days of supplementation with omega 3 |
| Biomarkers of oxidative stress | 28 to 32 weeks of pregnancy | Will be collected blood before and after 21 days of supplementation with omega 3 |
Countries
Brazil
Contacts
Primary ContactPaulo Zielinsky, Doctor
Backup ContactCamila Brum, Master
Outcome results
None listed