Olfaction Disorders in Patients Included in The Trauma Brain Injury (TBI) Database at Trondheim University Hospital

Olfaction Disorders in Patients Included in The Trauma Brain Injury (TBI) Database at Trondheim University Hospital: Prevalence and Treatment

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02565121

Enrollment

Registered

2015-10-01

Start date

2013-06-30

Completion date

2015-08-31

Last updated

2020-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Injuries, Olfaction Disorders

Keywords

Olfactory perception, Adrenal cortex hormones, Steroids, Education

Brief summary

The aim of the study is to see whether patients with chronic smell impairment after brain injury benefit from a treatment that consists of corticosteroids, and then olfactory training in 3 months.

Interventions

DRUGcorticosteroids

BEHAVIORALolfactory stimulation

stimulation with odorants by sniffing 4 different odorants for a total of 5 minutes twice a day during 3 months

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Registered in the TBI Database * 18-65 years of age per 01.10. 2012 * Olfaction score by Sniffin Sticks Threshold-Discrimination-Identification (TDI) \< 30 confirming dysosmia

Exclusion criteria

* Unable to express senses. * Unable to follow treatment and protocol * pregnancy * diabetes * tendency to infections * hypertonia * dyspepsia * interfering medication (hormonal treatment, NSAIDS, antidiabetics, barbiturates, fenitoin, carbamazepin, rifampicin, cyclophosphamides)

Design outcomes

Primary

Measure	Time frame	Description
number of patients who have improved olfaction perception (by at least 5 points on the Threshold-Discrimination-Identification (TDI) score	1 year	TDI score measured by Sniffin Sticks

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026