Healthy Volunteers
Conditions
Brief summary
It is well documented that a few days stay in space induces a change in the vestibular-ocular reflex reflecting a reinterpretation of sensory inputs following the disappearance of gravity. If the change of eye reflexes actually the result of a reinterpretation of sensory input, the investigators should also expect to see an alteration of the vestibular-cardiovascular reflexes. The modification of these reflexes may modulate the carotid baroreflex and thus participate in the post-flight cardiovascular deconditioning. The first objective of this project is to study the carotid baroreflex under different supine (dorsal, ventral and lateral) inducing different otolith stimulation in normal-gravity.
Interventions
PROCEDUREStimulation of the carotid baroreceptors with a pressure system
In each decubitus, trains of stimuli 8 (-80, -60, -40, -20, 0, 10, 20 and 40 Torr), with a duration of 500 milliseconds each, will be applied using a positive and negative pressure system placed around the neck of the subject.
Sponsors
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers, male and / or female aged 18-30 years * subject affiliated to a social security scheme, agreeing to participate in the study and who provided informed consent.
Exclusion criteria
* who participated in a clinical trial within less than the period of exclusion from this project * with a past or present history of heart disease, vascular, neurological, respiratory, rheumatological, metabolic or otologic. * pregnant women (dosage beta HCG) * having taken any medication heart, vascular, neurological, respiratory, rheumatological, metabolic or might interfere on vestibular test results during the two years preceding the experiment. * smoking or smoking more than 5 cigarettes / day, 1 cigarette / day or 1 pipe / day
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial flow in Common Carotid Artery (EchoDoppler) | baseline | Measurements of Common Carotid Artery Blood Flow in Cm/s |
| Arterial flow in Internal Carotid Artery (EchoDoppler) | Baseline | Measurements of Internal Carotid Artery Blood Flow in Cm/s |
| Arterial flow in External Carotid Artery (EchoDoppler) | Baseline | Measurements of External Carotid Artery Blood Flow in Cm/s |
| Arterial flow in Vertebral Artery (EchoDoppler) | Baseline | Measurements of Vertebral Artery Blood Flow in Cm/s |
Countries
France
Outcome results
None listed