Endocrine System Diseases
Conditions
Brief summary
With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.
Interventions
DIETARY_SUPPLEMENT0.52 g L-Tryptophan
DIETARY_SUPPLEMENT1.56 g L-Tryptophan
DIETARY_SUPPLEMENT1.56 g L-Leucine
DIETARY_SUPPLEMENT50 g Xylitol
DIETARY_SUPPLEMENT75 g Erythritol
DIETARY_SUPPLEMENT75 g Glucose
DIETARY_SUPPLEMENT300 mL tap water
OTHER50 mg 13C-sodium acetate
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy normal weight subjects with a body-mass index of 19.0-24.9 * Healthy obese subjects with a body-mass index of \> 30 * Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan) * Age 18-40 years * Stable body weight for at least three months
Exclusion criteria
* Smoking * Substance abuse * Regular intake of medications (except for oral contraceptives) * Medical or psychiatric illness * History of gastrointestinal disorders * Food allergies * Pregnancy, breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of different aminoacids and sugar alcohols on secretion of satiation hormones | changes from baseline to three hours after treatment | Plasma concentrations of glucose |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of different aminoacids and sugar alcohols on gastric emptying | changes from baseline to four hours after treatment | measured by C13 breath test |
Countries
Switzerland
Outcome results
None listed