Severe Cerebral Pathology
Conditions
Keywords
severe cerebral pathology, Ultrasound, thickness of the quadriceps
Brief summary
Intensive care unit acquired muscle weakness (ICUAW) is a common disease. After 7 days of mechanical ventilation, a quarter of patients develop an ICUAW responsible of a 15-20% of muscle loss. This is a serious pathology associated with high morbidity and mortality. Clinical diagnosis of ICUAW is difficult and need a patient awoken. CT scan and Magnetic Resonance Imaging (MRI) are considered as gold standards to quantify and monitor changes in muscle mass. But these tools are not adapted to ICU patients. Ultrasound (US) is an easy access tool at the bedside to assess muscle mass and does not expose the patient to additional radiation. The objective of this study is to evaluate the correlation between US and CT scan to measure quadriceps muscle thickness of ICU patients.
Detailed description
As part of the monitoring of the neurological disease, brain CT scans are frequently performed. At the same time, an acquisition sequence centered on the quadriceps will follow the brain sequences. Up to three brain CT scans coupled with a quadriceps imaging will be performed between the day of admission and on the tenth day of hospitalization. An ultrasound of the quadriceps will be performed concomitantly. The thickness of the quadriceps is measured by an independent operator on CT and ultrasound images.
Interventions
DEVICECT Scan and ultrasonography
Up to three measurements (CT scan and Ultrasonography) of the thickness of quadriceps, will be made concurrently .
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patient over 18 years admitted to intensive care for a severe brain injury (Glasgow \<8) and with a predictive duration of mechanical of at least 48hours
Exclusion criteria
* Pregnancy, * Bilateral trauma of thighs, * Coma induced by poisoning or by a metabolic disorder, * Morbid obesity (BMI \> 35).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concordance of the measurement of the quadriceps thickness by ultrasound and by CT scan | Between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) | Concordance of each of the three measurements of the thickness of quadriceps realised concurrently by CT scan and Ultrasonography (composite measure) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| kinetic of the thickness of quadriceps | Between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) | Evolution of he thickness of quadriceps measure concurrently by CT scan and Ultrasonography |
Countries
France
Outcome results
None listed