Acute Respiratory Failure, Hematological Malignancy, Mechanical Ventilation
Conditions
Keywords
Intensive care unit, Hematological malignancy, Acute respiratory failure, Prognosis, Mechanical ventilation
Brief summary
This observational cohort aimed to re-evaluate the outcome of hematologic cancer patients admitted to the intensive care unit of Mansoura oncology center through a cohort study as regards their need for mechanical ventilation during two years.
Detailed description
It has been believed for many years that the scene of cancer patients requiring mechanical ventilation is frustrating. The needed life support measures drain much of health resources and add a significant burden on the patient's family. Many factors have been responsible for the high mortality rates among hematologic cancer patients admitted to intensive care unit. Among of these factors, the invasive treatments that are frequently employed in today's intensive care unit. These procedures give chance for development of severe infection and multiple organ failure which are common events in immune-compromised patients (e.g. neutropenia) and in those exposed to chemotherapy. The most common form of organ failure in those patients is acute respiratory failure which is a major predictor of mortality in that population. The prognosis of such failure may vary depending on its causes and severity, co morbidity, associated acute organ failure and characters of the underlying malignancy. After the recent advances in the field of intensive care and shedding light on the benefits of the noninvasive ventilation in immune-compromised patients, the overall survival rate of cancer patients admitted to intensive care unit are improving.
Interventions
PROCEDUREMechanical ventilation
requiring mechanical ventilation at admission to ICU for one day or more during the study period
Sponsors
Mansoura University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Critical ill hematological cancer patient * Requiring mechanical ventilation
Exclusion criteria
* Patients with acute coronary syndrome. * Patients with cancer remission more than 5 years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival | through study completion, an average of 30 days after admission to intensive care unit | Continuing to live |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sequential Organ Failure Assessment score | up to 24 hours after admission to the intensive care unit | Sequential Organ Failure Assessment (SOFA) Score |
| Simplified Acute Physiology Score II | up to 24 hours after admission to the intensive care unit | Simplified Acute Physiology Score (SAPS II) |
| Mode of mechanical ventilation | up to 24 hours after admission to the intensive care unit | synchronised intermittent, pressure-controlled, volume-controlled, pressure support, continuous positive airway pressure, volume guarantee, adjusted pressure release ventilation, or adaptive proportional assist ventilation |
| lowest Pa02/FiO2 | up to 24 hours after admission to the intensive care unit | PaO2 arterial oxygen tension/FiO2 inspired fraction of oxygen ratio |
| Reason for need of ventilatory support | up to 24 hours after admission to the intensive care unit | Advanced malignancy, respiratory muscle weakness, respiratory failure, lung metastasis, coma, sepsis, multi-organs failure |
Other
| Measure | Time frame | Description |
|---|---|---|
| Associated comorbidities | up to 24 hours after admission to the intensive care unit | Like as sepsis, acute respiratory distress syndorme, or leukopenia |
| Cancer status | up to 24 hours after admission to the intensive care unit | Early or advanced stage |
Countries
Egypt
Outcome results
None listed