A Case Control Study of Patients With Diagnosis of Malignant Hyperthermia

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02561598

Enrollment

Registered

2015-09-28

Start date

2023-05-31

Completion date

2024-05-31

Last updated

2022-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant Hyperthermia

Brief summary

The purpose of the study is to develop methods to identify predictors of Malignant Hyperthermia.

Detailed description

The current study will use the combination of electronic medical records and genomic information in samples of persons who have exhibited signs of Malignant Hyperthermia (MH) or have family history or high risk of MH to see if risk factors can be identified. These will be compared with control samples of children who have been exposed to the same agents which could induce MH, yet showed no signs of the disorder.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Malignant hyperthermia cases: Diagnosis of malignant hyperthermia * Control cases: children who participated

Exclusion criteria

* Not meeting the inclusion criteria stated above

Design outcomes

Primary

Measure	Time frame	Description
Number of clinical manifestations of malignant hyperthermia	Within data collection period (3 years total).	Incidence of clinical manifestations of MH will be compared among patients with a history of MH to controls (no diagnosis of MH).

Secondary

Measure	Time frame	Description
number of Genetic indications for malignant hyperthermia	Within data collection period (3 years total).	genetic indications for malignant hyperthermia will be compared between control subjects and subjects with a diagnosis of MH

Countries

United States

Outcome results