Comparison Between spIgE and Skin Prick Test of Local and Imported Aeroallergens

In-vivo Potency Evaluation of American Cockroach, Dog, Cat, Dust Mites and Mold Allergen Extracts Produced by Siriraj Hospital Comparing With Imported Extracts by Using Skin Prick Test.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02561390

Enrollment

Registered

2015-09-28

Start date

2013-11-30

Completion date

2014-06-30

Last updated

2016-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immediate Hypersensitivity

Brief summary

The prevalence of Allergic rhinitis(AR) and asthma was increased world wide. In 1998, ISAAC found that prevalence of AR and asthma inThailand was in moderately high group. Tests for immediated reaction SPT and spIgE, were used for evaluated sensitization of allergen in patient. They guided the investigators for proper management as well as patient education. Clinician will use the result for choose allergen in case that might need immunotherapy. SPT is safe and more economic for patient. Specific IgE has an advantage in patient who cannot withhold antihistamine prior SPT. In United state had a trial of result between SPT and spIgE for cockroach, cat, house dust mite and mold. It showed the correlation between two tests. In Thailand, the investigators haven't had data about it yet.

Detailed description

SPT and specific IgE for allergens is necessary for allergen avoidance and specific immunotherapy. To have local allergen extracts will help the patients to easier get the appropriate management

Interventions

PROCEDURESkin prick test

skin prick test to American cockroach, dog, cat, dust mite and mold allergen extracts are performed

OTHERspecific IgE measurement

measure specific IgE of American cockroach, dog, cat, dust mite and mold

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

10 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Patient with controlled Asthma and/or AR (mild to moderate severity) who were diagnosed in Allergy clinic and ENT clinic, Siriraj hospital * SPT positve one of American Cockroach, House dust mite, cat, dog and mold. * Patient were consented to trial.

Exclusion criteria

* Chronic disease such as heart disease, liver, renal and severe sepsis * History of anaphylaxis * Skin rash * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
mean wheal diameter of SPT of local and imported allergen extracts and specific IgE levels	18 months	measure and compare SPT result of local and imported allergen extracts

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026