Prediabetic State
Conditions
Keywords
resistance training, Prediabetic state, Metabolomics
Brief summary
This study evaluates the efficacy of a 12-month resistance training on metabolic control and reducing the risk of diabetes.
Detailed description
Most of exercise interventions involved aerobic exercises, investigators were not able to find a single long term study focusing on type 2 diabetes prevention with resistance training and aerobic exercise. It has been known that for those who have already had diabetes, resistance training can reduce insulin resistance and HbA1c level, improve lipid profile, and decrease blood pressure. Based on previous findings, investigators will evaluate how the different exercising interventions impact on insulin resistance, metabolic control, and the incidence and prevalence of diabetes in prediabetes population who receive 12 months of either resistant training or aerobic exercise. Further more, metabolomics approach will be introduced to detect biological markers,and therefore,to analyze the predictive values of metabolomics on long term outcomes of prediabetes population.
Interventions
BEHAVIORALresistance training
Resistance training consisted of 6 different resistance exercises per session using elastic string, and each exercise progressed to 2-3 at maximum resistance lifted 8-10 times.
BEHAVIORALaerobic training
Aerobic training consisted of aerobic exercise and progressed from 15-20min/session at 60% maximum heart rate to 45-50min/session at 75% maximum heart rate.
Sponsors
Guangxi Medical University
Southeast University, China
Nanjing University of Traditional Chinese Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* a confirmed diagnosis of prediabetes according to the American Diabetes Association (ADA) guidelines * level 4 of muscle strength * willingness to accept exercise intervention * provision of written informed consent.
Exclusion criteria
* type 2 or other types of diabetes * women who are pregnant * hepatic dysfunction, as evidenced by alanine aminotransferase (ALT) or alkaline phosphatase (ALP) levels greater than 2.5-fold the upper limits of normal * crucial organ failure or other severe diseases, including myocardial infarction * malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| glycemic control | 6 months | Fasting blood glucose, postprandial blood glucose and HbA1c will be measured at 6 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| small molecule metabolites | 6 months | Biological markers, with the method of metabolomics approach, will be measured at 6 months |
| Incidence rate of diabetes | 6 months | Evaluate the incidence of diabetes in prediabetes population at 6 months. |
Countries
China
Contacts
Primary ContactQingqing Lou, director
Backup ContactLin Liu
Outcome results
None listed