Autoimmune Encephlitis in China
Conditions
Brief summary
In recent years, more and more previously thought to be unknown encephalitis was found to be a specific antigen associated encephalitis，but because of the lack of recognition in the clinic, usually been misdiagnosed as other causes of encephalitis. Therefore, it is urgent to establish a database of autoimmune encephalitis in Chinese population. The prospective clinical trial of atutoimmune encephalitis in China, by screening the autoimmune encephalitis associated antibody and summarizing the cases analysis, in order to provide evidence for clinical diagnosis and treatment of autoimmune encephalitis.
Interventions
None listed
Sponsors
Beijing Tiantan Hospital
Xuanwu Hospital, Beijing
Peking Union Medical College Hospital
Beijing Children's Hospital
Beijing Tongren Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Months to No maximum
Healthy volunteers
No
Inclusion criteria
1. Older than 6 months. 2. Encephalopathy symptoms (change of mental state and consciousness level) persist for more than 24 hours; 3. At least one or more clinical features of the followings: fever, epilepsy, focal neurological deficiency symptoms, changes in CSF(cerebrospinal fluid inflammatory), changes in EEG (electroencephalogram), radiographic abnormalities; 4. Clinical suspected encephalitis, but conventional detected methods cannot make etiology clear. 5. Signed the informed consent.
Exclusion criteria
1. Infants less than 6 months; 2. The metabolic encephalopathy; 3. Infectious encephalitis with clear pathogen clinically, referring the specific pathogenic microorganisms, including: bacteria, virus, fungus, parasite, spirochete and so on; 4. Non-infectious encephalitis with clear diagnosis clinically, including: multiple sclerosis, neuromyelitis optic, acute disseminated encephalomyelitis and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| death | 30days |
Outcome results
None listed