Healthy
Conditions
Keywords
Healthy Volunteers, Pain, EEG
Brief summary
Determine objective markers of pain perception remains a major scientific and medical issue. Various tools have been proposed to objectify pain, but their adaptability to different clinical contexts are limited. Our working hypothesis considers that the research for markers of immediate pain perception should be based on an electrophysiological approach, based on the combined analysis of EEG and autonomic responses.
Detailed description
This project aims to study the cortical and autonomic responses induced by tonic painful stimulation compared to those induced by comparable sensory and stressful stimulations, by combining high density EEG, cutaneous sympathetic, cardiovascular and pupillary recordings.
Interventions
OTHERPainful tonic stimuli
OTHERnon-painful stimuli
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Affiliate or beneficiary of social security * Signature of consent
Exclusion criteria
* History of cardiovascular disease (vagal syncope, hypertension, etc ...), renal, metabolic (diabetes ...), psychiatric (depression, etc ...) or neurological (seizure, etc ...) syndromes; * Reynaud's syndrome; * Raynaud's disease; * Acrocyanosis; * Known rhythm disorders; * Participation at the same time in another clinical trial; * Taking a medical treatment; * Suffering from acute (complaint of pain in the week before the test) or chronic pain, * Allergic to conductive gel for electrodes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG Gamma power. | Baseline | The EGG signals are compared between a painful stimuli tonic to those evoked by non-painful stimuli. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ratio of low to high frequency spectral powers | Baseline | The low and high frequency spectral powers are measured by an ECG Holter. The ratio are compared between a painful stimuli tonic to those evoked by non-painful stimuli. |
| Magnitude of the sympathetic cutaneous reactivity | Baseline | The sympathetic cutaneous reactivity is measured by an acquisition system (ME6000, MEDIMEX, France) with one electrode on the hand. The magnitudes are compared between a painful stimuli tonic to those evoked by non-painful stimuli. |
| Amplitude of pupillary dilation | Baseline | The pupillary dilation is measured by the ISCAN® system (MA, USA). The amplitudes are compared between a painful stimuli tonic to those evoked by non-painful stimuli. |
Countries
France
Outcome results
None listed