Brain Lesions
Conditions
Keywords
Eloquent cortex
Brief summary
Currently, standard-of-care tractography is based on information obtained from diffusion tensor imaging (DTI). DTI is a diffusion magnetic resonance imaging (dMRI) technique that is routinely obtained on neurosurgical patients to assist in pre-operative planning. The primary objective of the proposed study is to determine the ability of msHARDI-based tractography to discern fibers in edematous brain regions.
Interventions
OTHERMRI
Sponsors
Abramson Cancer Center at Penn Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* brain lesions, including but not limited to tumors, epileptic foci, and vascular abnormalities, in or around eloquent brain regions (i.e., motor, language); * clinical need for pre-operative 'advanced imaging' (which includes conventional DTI); * age between 18-80 years of age; * male or female gender. Eloquent regions include: Temporal and frontal lobes (speech/language); bilateral occipital lobes (vision); bilateral parietal lobes (sensation); and bilateral motor cortex (movement).
Exclusion criteria
* a contraindication for obtaining an MRI scan (e.g. implanted devices, retrained foreign body) * pregnancy * absence of the capacity to make medical decisions or provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of subjects providing completion of the neurocognitive battery | 2 years |
Countries
United States
Outcome results
None listed