Paroxysmal Atrial Fibrillation
Conditions
Brief summary
Radiofrequency catheter ablation is effective in the treatment of patients with paroxysmal atrial fibrillation. In order to reduce the recurrence rate after catheter ablation, the investigators propose to apply 'virtual' ablation on patient-specific atria by simulating 3D atrial computer model. The investigators will conduct virtual rotor mapping in the patient specific atrial model. Then, the investigators will compare the clinical outcome of conventional circumferential pulmonary vein isolation and additional rotor ablation guided by virtual rotor mapping.
Interventions
PROCEDUREphysician's personal experience
physician's personal experience
PROCEDUREVirtual rotor mapping
Virtual rotor mapping
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* AF patient age 19\ 80 * Diagnosis of AF patients who performed catheter ablation of atrial fibrillation due to uncontrolled pulse rate by anti-arrhythmic drug therapy.
Exclusion criteria
* AF patients who have severe heart deformations or vascular disease. * The patient who have renal disease of eGFR\<30mL/min * The patients who had been performed catheter ablation of atrial ablation and MAZE. * The patients who missed out to recording of 3D CT, echo and electrocardiography. * the patient have experienced major hemorrhagic complication * The patient have experienced ischemic cerebral infarction more 2 times * The patient who have risk of ischemic cerebral infarction (CHA2DS2-VASc Score \>5)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence rate of atrial fibrillation of 18 months after procedure within 18 months | 18 months |
| Rate of mortality, incidence of cerebral infarction and hospitalization after procedure | 24 months |
Secondary
| Measure | Time frame |
|---|---|
| Major complication related procedure : Complication of hemorrhagic and embolic | 24 months |
| Pericardial effusion required treatment, 4g/dL reduced level of Hb, Hemorrhage required blood transfusion and Cerebral infarction related procedure | 24 months |
| Procedure time and Radiofrequency ablation time | 24 months |
Countries
South Korea
Contacts
Primary ContactHui-Nam Pak
Outcome results
None listed