Alcohol Dependence
Conditions
Keywords
Repetitive Transcranial Magnetic Stimulation, Emotion Regulation, Craving
Brief summary
This current project investigates the effect of a single session of right dlPFC repetitive transcranial magnetic stimulation on emotion regulation abilities and craving in alcohol dependent patients and healthy controls.
Interventions
DEVICERepetitive Transcranial Magnetic Stimulation
Repetitive 10Hz right DLPFC stimulation using Magstim TMS apparatus
Sponsors
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Alcohol Dependence * Currently abstinent
Exclusion criteria
* psychoactive medication * not eligible for MRI (metals or claustrophobia) * (familial) history of epilepsy * current psychiatric disorders (besides alcohol dependence)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in BOLD response during an emotion regulation task (fMRI) | Change in BOLD response from baseline, compared to BOLD response after stimulation (approximately two weeks later) | BOLD response was measured during an emotion regulation task. The change in BOLD response between sessions is the primary outcome for this study |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in experienced emotion during an emotion regulation task with Visual Analogue Scales (VAS) | Change in experienced emotion from baseline, and after the stimulation session (approximately two weeks later) | Participants were instructed to either 'attend' or 'regulate' their emotion associated with the presented (negatively valenced) pictures. Experienced (or regulated) emotion was assessed with visual analogue scales (VAS). |
| Change in craving levels [Alcohol Urge Questionnaire (AUQ)] | Before and after the emotion regulation task, during both baseline and stimulation session (e.g. 4 time points, sessions were separated by approximately two weeks) | The AUQ was administered in order to assess craving levels. The AUQ consists of eight statements wich are rated on a 7 point likert scale \[0 = Strongly disagree, 6 = Strongly Agree\] |
Outcome results
None listed