Muscle Hypertrophy in Healthy Young Men
Conditions
Brief summary
The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.
Interventions
OTHERNo training
OTHEREndurance training
OTHERResistance Training
DRUGTerbutaline
DRUGClenbuterol
DRUGPlacebo
Sponsors
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy young men * 18-35 years of age * Informed consent * Active 2-5 hours of training pr. week * Maximal oxygen uptake (ml/min/kg) of 40-60 * Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2
Exclusion criteria
* Smoker * Allergy towards study drugs * Chronic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle hypertrophy (lean body mass in Kilograms) | 2 days | Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Energy turnover (ml/min or mmol/kg dry weight muscle) | 1 day | Pulmonary gas exchange and lactate and glycogen will be measured in muscle biopsies obtained before and after intense exercise |
Countries
Denmark
Contacts
Primary ContactMorten Hostrup, PhD
Outcome results
None listed