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Optimal Volume of Bupivacaine in Adductor Canal Nerve Block

Optimal Volume of Bupivacaine in Adductor Canal Nerve Block in Patients Undergoing Unilateral Cruciate Ligament Reconstruction Surgery

Status
UNKNOWN
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02557386
Enrollment
60
Registered
2015-09-23
Start date
2016-01-31
Completion date
2017-03-31
Last updated
2016-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Local

Keywords

Cruciate ligament surgery, Adductor canal, Nerve block

Brief summary

To establish adequate volume of levobupivacaine 0.25% in adductor canal nerve block in unilateral cruciate ligament of the knee reconstruction surgery.

Detailed description

The complex knee surgery has been associated with severe postoperative pain. Different analgesic techniques for postoperative management of this increasingly common surgery, with main purpose of adequately control pain, minimizing adverse effects and seeking early rehabilitation. Currently, the most used technique is the continuous femoral nerve block, which is able to control postoperative pain well, but has the limitation that also produces motor blockade, decreasing quadriceps strength up to 80%, increasing the number of falls and delaying early mobilization after surgery. On the other hand, the adductor canal nerve block is an alternative as it is considered a purely sensitive block. The nerves that are in this channel are the saphenous adductor nerve, posterior branches of the obturator nerve, medial vast nerve, sometimes the medial cutaneous nerve and anterior branches of the obturator nerve and the vast medial nerve. With regard to the adductor canal block, current literature supports analgesic effect comparable to femoral nerve block with less motor block than femoral nerve block. However, there is no clarity regarding the ideal concentration and volume of local anesthetics to use. Volumes ranging from 5 to 30 ml have been used in different studies. For example, using 20 mL of local anesthetic in femoral nerve block has produced scattering of anesthetic that has blocked motor branches. The investigators objective is to determine which volume of levobupivacaine 0.25% is necessary to produce analgesia and sensitive blockade while minimizing motor blockade in adductor canal nerve block in patients undergoing cruciate ligament reconstruction surgery.

Interventions

DRUGLevobupivacaine 5 mL

Levobupivacaine 0.25% 5 mL in adductor canal nerve block

DRUGLevobupivacaine 10 mL

Levobupivacaine 0.25% 10 mL in adductor canal nerve block

DRUGLevobupivacaine 15 mL

Levobupivacaine 0.25% 15 mL in adductor canal nerve block

DRUGLevobupivacaine 20 mL

Levobupivacaine 0.25% 20 mL in adductor canal nerve block

DRUGLevobupivacaine 25 mL

Levobupivacaine 0.25% 25 mL in adductor canal nerve block

DRUGLevobupivacaine 30 mL

Levobupivacaine 0.25% 30 mL in adductor canal nerve block

Sponsors

Pontificia Universidad Catolica de Chile
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Male sex * ASA status I or II * BMI between 20 and 34 kg/m2 * Cruciate ligament of the knee reconstructive surgery * No contraindications to general and regional anesthesia

Exclusion criteria

* Chronic pain more than 3 months * Drug abuse * Chronic use of analgesic drugs (more than 3 months) * Psychiatric illness * Peripheral neuropathy * Drug allergy * Severe gastroesophageal reflux disease

Design outcomes

Primary

MeasureTime frameDescription
Change in quadriceps motor force measured in kg*m/sec2Before nerve block (basal) and 24 hours after surgeryUsing a dynamometer in anterior tibial muscle

Secondary

MeasureTime frameDescription
PainBefore surgery, 30 minutes after nerve block, one hour after surgery, 48 hours after surgeryUsing visual analogue scale, static and dynamic evaluation, scale from 0 (no pain) to 10 (worst pain imaginable)
Rescue analgesia24 hours and 48 hours after surgeryLidocaine 1% bolus through nerve block catheter and opioid use, measured in mg
Patient satisfaction48 hours after surgeryUsing a 5 point scale from 1 (very unsatisfied) to 5 (very satisfied)
Change in quadriceps force measured by 30-second chair stand testBefore nerve block (basal) and 24 hours after surgeryUsing 30-second chair stand test, how many times patient can stand up in 30 seconds, number of times is recorded
Sensitivity block30 minutes after adductor canal blockUsing a sensitivity scale ranging from 0 (no sensitivity), 1 (paresthesias) and 2 (normal sensitivity. Measured with needle prick and cold sensitivity.

Countries

Chile

Contacts

Primary ContactFernando R Altermatt, MD
falterma@med.puc.cl56-2-23543270

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026