End Stage Renal Disease
Conditions
Brief summary
The objective of this study is to determine the effectiveness of treating peritoneal dialysis (PD) patients with fluid overload by a structured nurse-lead intervention protocol. We plan to recruit 100 PD patients with fluid overload. These patients will be assessed and managed by a renal nurse specialist in the ambulatory renal center according to a standardized protocol. The improvement in the degree of overhydration will be determined by bioimpedance spectroscopy 4 and 12 weeks after treatment.
Detailed description
Fluid overload is a common problem in peritoneal dialysis (PD) patients and it is associated with left ventricular hypertrophy and other adverse cardiac consequences. Fluid management is therefore an important aspect in the management of dialysis patient. In Hong Kong, PD patients with common medical problems related to dialysis are assessed and managed in the renal nurse clinic by pre-approved intervention protocols. Although it is the general impression that management of PD patients with fluid overload by a nurse-lead intervention protocol is robust and could reduce the work load of medical staff, the efficacy of this approach remains undetermined. The objective of this study is to determine the effectiveness of treating PD patients with fluid overload by a structured nurse-lead intervention protocol. We plan to recruit 100 PD patients with fluid overload, which is defined as overhydration (OH) ≥ 2 litres as measured by bioimpedance spectroscopy. These patients will be assessed and managed by a renal nurse specialist in the ambulatory renal center according to a standardized protocol previously approved by the Hospital Authority. The improvement in the degree of overhydration will be determined by bioimpedance spectroscopy 4 and 12 weeks after treatment. Change in body weight, blood pressure, degree of oedema, as well as the knowledge on salt and fluid restriction will also be assessed.
Interventions
BEHAVIORALAggressive fluid management
nursing education, dietary advice, extra hypertonic dialysis cycles
Sponsors
Chinese University of Hong Kong
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* PD patients with overhydration (OH) ≥ 2 litres as measured by bioimpedance spectroscopy
Exclusion criteria
* overt pulmonary edema and required urgent medical care * cognitive impairment or problem of communication * unlikely to survive for more than three months * mechanical problems of the dialysis catheter * active peritonitis or peritoneal failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| degree of overhydration | 12 weeks | measured by bioimpedance spectroscopy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | 12 weeks | — |
| patient knowledge | 12 weeks | questionnaire assessment |
Countries
Hong Kong
Outcome results
None listed