Epigenetic Changes, Neurodevelopmental Disorder, Preterm
Conditions
Brief summary
Approximately 2% of neonates in the US are born very preterm. Preterm births are associated with impaired cognitive, language and motor function, and increased risk for autism spectrum disorders. Epidemiological studies indicate a dose-response relationship between gestational age at delivery and cognitive impairments, with the most immature of newborns being the most susceptible to developmental delays. Sensitive and reproducible biomarkers of long-term neurocognitive impairments are currently lacking. The investigators seek to identify epigenetic markers that mediate the relationship between adverse prematurity-related exposures and neurocognitive impairments. The overarching hypothesis of this proposal is that DNA methylation profiles of CD34+ hematopoetic progenitor and stem cells from very preterm infants can be used as a risk-stratifying biomarker for predicting neurocognitive impairment in childhood.
Interventions
OTHERObservational study
Sponsors
Albert Einstein College of Medicine
Montefiore Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 2 Days
Healthy volunteers
No
Inclusion criteria
* \<32 weeks gestation * Born at Weiler Division of Montefiore
Exclusion criteria
* Intraventricular hemorrhage * Chromosomal abnormalities * Congenital viral conditions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain white matter development | 38-42 weeks adjusted age | Brain MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurodevelopment | 38-42 weeks adjusted age | Administration of NICU Neonatal Neurobehavioral Scale |
Countries
United States
Outcome results
None listed