Memory Loss
Conditions
Keywords
subjective memory impairment, cognitive training
Brief summary
This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.
Detailed description
Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.
Interventions
BEHAVIORALcognitive training
cognitive training is held 2 times a week for 3 months, 90 minutes per 1 session. It includes cognitive exercise of multiple cognitive domains such as memory, attention, calculation, executive function and visuospatial function.
BEHAVIORALlifestyle modification
education about lifestyle modification is done by investigators at the first day of the trial and the investigators conduct weekly phone call to participants to educate the lifestyle modifications
Sponsors
Asan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Subjects who showed normal range (above 16percentile of norm) in all domains of detailed neuropsychological tests battery named Seoul Neuropsychological Screening Battery (SNSB) * Clinical dementia rating (CDR) score of 0 * Subjects with at least 3 years of formal education
Exclusion criteria
* Subjects with mild cognitive impairment or dementia * Subjects who was diagnosed as any neurological disorders such as epilepsy, stroke, hemorrhage, hydrocephalus, Parkinson's disease or brain tumor * Subjects with uncontrolled severe medical conditions according to investigator's opinion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Paired associates learning test | 3 month | paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors. |
| Rapid visual information processing test | 3 month | rapid visual information processing is a part of computerized neuropsychological test battery named CANTAB. The score is shown as correct response rate.% |
| Pattern recognition memory test | 3 month | paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The score is shown as correct response rate.% |
| Spatial working memory test | 3 month | paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Seoul instrumental activities of daily living | 3 month | scale for measuring activities of daily living limitation. score range 0-45. low score means better ability. |
| Rey complex figure copy test | 3 month | test for visuospatial function. Participants should copy the complex figure. score range: 0-36. Higher score means better visuospatial function. |
| Digit symbol test | 3 month | a test for attention and psychomotor speed. Participants are instructed to write an appropriately matched code for each number. Correct number is counted. score range: 0-76. Higher score means better function. |
| cognitive failure questionnaire | 3 month | questionnaire for measuring self reported cognitive status. score range: 0-100. Higher score means worse cognitive status. |
| Seoul verbal learning test, delayed recall | 3 month | measuring tool for 20 minutes delayed memory function. After 20 minutes from the immediate recall test, participants should remember the words. score range: 0-12. Higher score means better delayed memory function |
| Logical memory test, delayed recall | 3 month | logical memory test is a part of a neuropsychological test named Wechsler |
| Seoul verbal learning test, immediate recall | 3 month | measuring tool for immediate memory function. Investigators read 12 words to participants. Participants should remember the words. Tests are done 3 times. score range: 0-36. Higher score means better immediate memory function |
| Mini-mental state examination | 3 month | mini-mental state examination that examines general cognition. range 0-20. Higher score means better cognition. |
| Geriatric depression scale | 3 month | questionnaire for depression measuring. score range:0-15. lower score means less depression. |
| Beck anxiety index | 3 month | questionnaire for self reporting anxiety measuring. range:0-63. low score means less anxiety. |
Countries
South Korea
Outcome results
None listed