Effect of Preoperative Oral Carbohydrates on Quality of Recovery

Effect of Preoperative Oral Carbohydrates on Quality of Recovery: Randomized Controlled Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02555020

Acronym

laparoscopy

Enrollment

153

Registered

2015-09-21

Start date

2015-09-30

Completion date

2016-12-23

Last updated

2017-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Evidence of Cholecystectomy

Brief summary

Carbohydrate loading is an important component of enhanced recovery pathways. Preoperative carbohydrate treatments have been widely adopted as part of enhanced recovery after surgery (ERAS) or fast-track surgery protocols. Although fast-track surgery protocols have been widely investigated and have been shown to be associated with improved postoperative outcomes, some individual constituents of these protocols, including preoperative carbohydrate treatment, have not been subject to such robust analysis.To assess the effects of preoperative carbohydrate treatment, compared with placebo or preoperative fasting, on postoperative recovery and insulin resistance in adult patients undergoing elective surgery.

Detailed description

Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal.

Interventions

DIETARY_SUPPLEMENTAllocated to Carbohydrated group

DIETARY_SUPPLEMENTAllocated to Placebo group

Patients received 400 mL of oral free water (Placebo) 12 hours before anesthesia and 400 mL 2 hours before.

DIETARY_SUPPLEMENTAllocated to MN NPO group,

Patients received NPO from MN.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

1. ASA (I/II) 2. Laparoscopic cholecystectomy. 3. KAROFSKY PERFORMANCE SCALE \>70, 4. No history of major operation

Exclusion criteria

1. DM patients 2. GE reflux Hx patients. 3. No- compliance, 4. Previous Abdominal Surgery History

Design outcomes

Primary

Measure	Time frame	Description
Quality of Recovery score using the QoR-40 Questionnaire	We check the QoR-40 at POD1 after cholecystectomy , an expected average 3days	We check the QoR-40 Questionnaire at discharge day

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026