Transciptomic Modification Induced by miRNAs in Endometrial Fluid

Human Embryonic Transciptomic Modification Induced by miRNAs Secreted by Human Endometrium to Endometrial Fluid

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02554539

Acronym

miRNA_EF

Enrollment

Registered

2015-09-18

Start date

2015-07-01

Completion date

2017-07-01

Last updated

2018-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MicroRNA in Endometrial Fluid

Brief summary

The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo. The investigators are interested in understanding how the in-utero environment during the window of implantation is different in normal weight and overweight/obese women and how this may impact the programming of the developing embryo.

Interventions

PROCEDUREEndometrial fluid aspiration

Patient will undergo a biopsy to aspirate endometrial fluid from the uterine cavity

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

21 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Meet the WHO criteria for normal weight (BMI \< 25) and overweight/obese (BMI \> 25) * Age 21-45

Exclusion criteria

* Age \< 21 or \> 45 * Women with history of hysterectomy

Design outcomes

Primary

Measure	Time frame	Description
Gene expression profile in human embryos	Samples will be collected within 1 month of enrollment	We will perform RNA sequencing on the human embryo to quantify which genes are up and down regulated in obese compared to normal weight controls.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026