Fractured Metacarpal Bone, Fractured Scaphoid Bone, Intact Metacarpal Bone, Intact Scaphoid Bone
Conditions
Brief summary
In trauma surgery and hand surgery treatment strategies of none healing bone fractures aim at replacing pseudarthrosis by well vascularized bone and improving microcirculation. Although previous studies indicate that remote ischemic preconditioning (RIPC) can accelerate bone healing in case of non-union, only a few studies focused on the elucidation of its mechanisms of action. Therefore, the aim of this study is to evaluate the microcirculatory effects of remote ischemic preconditioning (RIPC) on scaphoid bones and metacarpal bones and metatarsal bones in a human in-vivo setting for the first time.
Interventions
PROCEDURERemote Ischemic Preconditioning (by Blood Pressure Cuff)
Remote Ischemik Preconditioning is performed using a Blood Pressure Cuff with a pressure slightly above patients' blood pressure on the upper arm.
Sponsors
University Hospital Schleswig-Holstein
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Group A (n=20): Consent-capable male and female patients ≥18 years of age who have an intact scaphoid bone. * Group B (n=20): Consent-capable male and female patients ≥18 years of age who have an intact metacarpal bone. * Group C (n=20): Consent-capable male and female patients ≥18 years of age who have a fractured scaphoid bone. * Group D (n=20): Consent-capable male and female patients ≥18 years of age who have a fractured metacarpal bone.
Exclusion criteria
* below 18 years of age * scar tissue above measuring focus * osteoporosis or comparable bone disease * medication that influences bones
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in microcirculation (composite outcome measure) | Baseline and 1 minute post-dose | * Bone blood flow \[arbitrary units AU\] * Bone blood velocity \[AU\] * Tissue oxygen saturation \[%\] * Relative postcapillary venous filling pressure \[AU\] (Composite outcome measure) |
Countries
Germany
Outcome results
None listed