Schizophrenia
Conditions
Keywords
violence, PET, omega-3 fatty acid, schizophrenia, patient
Brief summary
Investigators plan to explore whether Omega-3 fatty acid have effect on the violent behavior of the schizophrenia patients. Investigators will use PET to explore the influence on serotonin function of the brain to understand the mechanism of how Omega-3 fatty acid works. This study will enroll 100 patients of schizophrenia with violent behavior.Participants will be split into two groups randomly. In one group, participants will receive one pill of placebo per day, and in the other, participants will have one pill of 900mg Omega-3 fatty acid per day. This intervention will last 3 months.At week 0, week 4, week 8 and week 12, some scales will be evaluated. Meanwhile, the density of eicosapentaenoic acid(EPA),docosahexaenoic acid (DHA),noradrenalin(NE), dopamine(DA) and serotonin(5-HT) in blood will be tested.At week 0 and week 12, 10 patients of each group will be randomly selected to have the exam of PET.
Interventions
BIOLOGICALomega-3 fatty acid
omega-3 fatty acid
BIOLOGICALplacebo
placebo
DEVICEpositron emission tomography (PET)
Sponsors
Shanghai Mental Health Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* the sore of MOAS scale \>=4 more than 2 violent behavior in recent 6 months by self repot
Exclusion criteria
* serious diseases,such as cardiovascular diseases,nervous system disease. allergy to fish oil
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| violent behavior of Participants as Assessed by Modified Overt Aggression Scale(MOAS) | up to 24 months | change in violent behavior of participants |
| psychiatry symptoms of participants as assessed by Positive and Negative Syndrome Scale (PANSS) | up to 24 months | change in psychiatry symptoms of participants |
| blood level of eicosapentaenoic acid(EPA), docosahexaenoic acid (DHA), noradrenalin(NE), dopamine(DA) and serotonin(5-HT) of participants | up to 24 months | change in the blood level of DHA, EPA, 5-HT, DA and NE at baseline, 4 weeks, 8 weeks and 12 weeks |
| the density of 5-HT1A receptor in brain tested by positron emission tomography (PET) | up to 24 months | change of the density of 5-HT1A receptor in different groups |
Countries
China
Contacts
Primary ContactYi Qiao, phD
Outcome results
None listed