Preconditioning With Sevoflurane and Propofol in Patients Undergoing Minimally Invasive Mitral Valve Surgery

A Single-center Observational Study Investigating the Effect of Volatile Conditioning (VC) With Sevoflurane on Myocardial Biomarkers and Platelets Function in Patients Having Minimally Invasive Mitral Valve Surgery (MIMV)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02551328

Acronym

MINI-SEVO

Enrollment

Registered

2015-09-16

Start date

2015-06-30

Completion date

2016-09-30

Last updated

2015-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Ischemia

Brief summary

Detailed description

The main aim of this study is to compare markers of cardiac injury (Troponin I), inflammatory response and platelets function during minimally invasive mitral valve repair or replacement (MIMV) via right mini-thoracotomy in two standard anaesthetic regimes: * Volatile conditioning (sevoflurane) used during induction (preconditioning) and during the operation as maintenance (perconditioning) and no propofol. * Propofol induction and maintenance (TIVA) and no volatile anaesthetics. Outlet/residual blood samples coming from routine check will be collected at different time points. Study will be powered on Troponin I (primary statistical outcome). Original secondary outcome will be considered: platelets activation, left ventricle function, clinical figures (length of stay, inotrops requirements, ventilation times and other relevant).

Interventions

DRUGsevofluorane

Continuous infusion of sevofluorane

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age ≥18 2. Patients undergoing elective (or urgent) first-time minimal invasive mitral valve surgery.

Exclusion criteria

1. Cardiogenic shock or cardiac arrest, emergent CABG 2. Renal failure (with a GFR \< 30 ml/min/1.73m2), 3. Glibenclamide or nicorandil (as these medications may interfere with VC) 4. Pregnancy 5. Known intolerance/allergy to sevoflurane or propofol

Design outcomes

Primary

Measure	Time frame	Description
Myocardial Injury assessed by changes in Troponin values	properatively-6, 12, 24, 48 and 72 hours after the end of ischaemic cardioplegic arrest	According to the routine post operative blood testing frame-time troponin sample will collected in the preoperative and postoperative period.

Countries

Italy

Contacts

Primary ContactAlessandra Parlanti, Pharmacist

alessandra.parlanti@ftgm.it-parlantialessandra@gmail.com0039/0585/493675/493565

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026