Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy

Role of 11 Weeks of Beta2-adrenergic Signaling and Resistance Training for Cardiac and Skeletal Muscle Hypertrophy in Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02551276

Enrollment

Registered

2015-09-16

Start date

2013-11-30

Completion date

2015-11-30

Last updated

2016-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Hypertrophy in Healthy Young Men

Brief summary

Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.

Interventions

DRUGSalbutamol

DRUGPlacebo

OTHERResistance training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Physical active * Non-smokers * Non-asthmatics * No chronic diseases * Informed consent

Exclusion criteria

* Smoker * Allergy towards study drug

Design outcomes

Primary

Measure	Time frame	Description
Skeletal Muscle Hypertrophy (lean body mass in Kilograms)	2 days	Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)

Secondary

Measure	Time frame	Description
Left Ventricular Hypertrophy (mass in grams)	1 day	Left Ventricular Mass (g) will be measured by echocardiography of the heart

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026