Chronic Kidney Disease, Chronic Obstructive Pulmonary Disease, Heart Failure, Malignancy
Conditions
Brief summary
This study aims to evaluate prevalence of sarcopenia and cachexia in patients with chronic cardiopulmonary disease. The investigators will also investigate metabolic disorders like glucose metabolism, presence of metabolic syndrome, body composition and histological changes in skeletal muscle and body fat. Finally, patients will be followed for clinical endpoints.
Interventions
None listed
Sponsors
University of Ljubljana
General Hospital Murska Sobota
Maastricht University
General and Teaching Hospital Celje
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* diagnosis of chronic disease (Heart failure, COPD, malignancy, CKD) or no diagnosis (controls)
Exclusion criteria
* refuse to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin resistance (HOMA-IR) | Baseline | HOMA-IR as calculated by formula using insulin and blood glucose |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength (Handgrip test) | Baseline | Handgrip test |
| Change in exercise capacity (6 minute walk test) | baseline and after 5 weeks | Determined by incremental exercise test, 6 minute walk test |
| Neurohormonal activation (NT-proBNP concentration) | Baseline | NT-proBNP concentration |
| Change in apoptosis in skeletal muscle (number of apoptotic cells per square mm) | Baseline and after 5 weeks | histological evaluation: number of apoptotic cells per square mm |
| Change in insulin resistance (HOMA-IR) | Baseline and after 5 weeks | HOMA-IR as calculated by formula using insulin and blood glucose |
Countries
Slovenia
Contacts
Primary ContactMitja Lainscak
Outcome results
None listed