Transgendered Persons
Conditions
Brief summary
This study plans to learn more about puberty blockers and cross (testosterone and estradiol). There is not much known about how these medications affect hormone levels, heart health and overall general health in young transgender individuals.
Detailed description
This study plans to learn more about puberty blockers and cross (testosterone and estradiol). There is not much known about how these medications affect hormone levels, heart health and overall general health in young transgender individuals.
Interventions
None listed
Sponsors
University of Colorado, Denver
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
9 Years to 21 Years
Healthy volunteers
No
Inclusion criteria
* Followed in Endocrinology Clinic or Adolescent Medicine Clinic at Children's Hospital Colorado * Between age 9 and 21 years (inclusive) * Identifies as transgender * Has been on pubertal blockade or cross-sex hormones for at least three months.
Exclusion criteria
* Known diabetes * Presence of significant medical or psychiatric comorbidities * Using hormones not prescribed by a physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reproductive hormone concentrations in transgender youth on cross-sex hormones and/or puberty blockers and compared to age-, natal sex- and body mass index (BMI)-matched controls. | at enrollment |
| Markers of cardiometabolic risk in transgender youth on cross-sex hormones and/or puberty blockers and compared to age-, natal sex- and BMI-matched controls | at enrollment |
| Body composition as measured by Dual-energy X-ray absorptiometry (DEXA) in transgender youth compared to age- and BMI-matched controls of both sexes. | at enrollment |
| Data on quality of life as measured by the Pediatric Quality of Life Inventory (PedsQL) compared to published norms | at enrollment |
Countries
United States
Outcome results
None listed