Stroke
Conditions
Keywords
Exercise training, Oxygen consumption
Brief summary
The purpose of this study is to examine if high intensity interval training after stroke is more effective than standard care to increase maximal oxygen uptake, reduce known risk factors for recurrent stroke and improve function.
Detailed description
Stroke is a leading cause of adult disability. Well designed studies have shown that the majority of the stroke population have low aerobic capacity and many are inactive. This is negative for their health and well-being. Physical inactivity may increase their risk of having recurrent stroke. The optimal training mode and intensity to improve aerobic capacity after stroke are not clear. High intensity interval training (ie. 90-95% of peak heart rate) has been proven to be more beneficial than moderate and low intensity exercise in order to improve maximal oxygen uptake in patients with cardiac disease. The response from this training on aerobic capacity and physical function in the stroke population are not known.
Interventions
BEHAVIORALHigh intensity interval training
Uphill treadmill walking
BEHAVIORALGeneral information
Standard care
Sponsors
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Approved informed consent * Independent walking \> 2 minutes * First episode of stroke (ischemic or hemorrhagic) * Minimum 3 months post-stroke * Living in the community and able to travel to assessment and training site * Approval to participate from the study's responsible medical doctor * Modified Rankin Scale 0-3
Exclusion criteria
* Impaired cognitive function to give valid informed consent to participate * Instability of cardiac conditions (ie. serious rhythm disorder, valve malfunction) * Other conditions where test of maximal oxygen uptake is contraindicated * Poorly controlled hypertension (\>180/100), measured at rest * \> 5 years post stroke * Subarachnoid hemorrhage * Participating in other ongoing intervention study * Other serious illness influencing testing of cardiorespiratory fitness and function at 1 year follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal Oxygen Uptake | 1 year after inclusion | A graded treadmill test of maximal oxygen uptake using a breath by breath ergospirometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Self reported physical activity level assessed by International Physical Activity Questionnaire | 8 weeks and 12 months after inclusion | — |
| Cognitive function assessed by Montreal Cognitive Assessment and Trail Making A and B | 8 weeks and 12 months after inclusion | — |
| Walking distance | 8 weeks and 12 months after inclusion | Walking distance (in meters) will be measured with the 6 minute walk test. |
| Change in blood pressure (systolic and diastolic) | 8 weeks and 12 months after inclusion | Blood pressure will be measured at rest |
| Walking speed | 8 weeks and 12 months after inclusion | Walking speed (in minutes:seconds) will be measured with the 10 meter walk test and the Timed Up and Go test. |
| Leisure time activity and inactive time | 8 weeks and 12 months after inclusion | Using the ActivePal monitor attached to the participants non-affected leg information on position, walking and inactive time will be measured during 3 whole consecutive days. |
| Balance tested with the Bergs Balance Test | 8 weeks and 12 months after inclusion | — |
| Change in Blood tests | 8 weeks and 12 months after inclusion | The following blood tests will be taken: Hemoglobin, HDL, LDL, Cholesterol, Total Cholesterol, C peptides, Triglycerides and HbA1c |
| Independence assessed by Functional Independence Measure (FIM) | 8 weeks and 12 months after inclusion | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| Anxiety and depression after stroke | 8 weeks and 12 months after inclusion | Hospital and Anxiety and Depression Scale will be used to get information about the participants level of anxiety and depression |
| Degree of disability and dependence | 8 weeks and 12 months after inclusion | Modified Rankin Scale (mRS) |
| Health status assessed by The Norwegian version of EQ-5D-5L questionnaire | 8 weeks and 12 months after inclusion | — |
| Submaximal oxygen consumption during treadmill walking | 8 weeks and 12 months after inclusion | Oxygen consumption will be measured at a standardized speed and inclination. |
| New cardiovascular or cerebrovascular incidents | 8 weeks and 12 months after inclusion | Gathered from the participants and their electronic journal system |
| Severity of stroke | 8 weeks and 12 months after inclusion | The Stroke Impact Scale will be used to evaluate how the stroke has affected the participants' health and life in addition to the National Institute of Health Stroke scale |
Countries
Norway
Outcome results
None listed