PAI-1 Expression in Non-scarring Hair Loss

Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02548689

Enrollment

Registered

2015-09-14

Start date

2015-07-31

Completion date

2021-06-30

Last updated

2022-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia Areata, Androgenetic Alopecia, Telogen Effluvium

Keywords

alopecia, hair loss

Brief summary

This study will investigate whether subjects who suffer from hair loss have increased levels of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be determined in subjects without hair loss and in subjects with non-scarring hair loss, including androgenetic alopecia, telogen effluvium and alopecia areata.

Detailed description

This study will compare the levels of PAI-1 expression in subjects with different forms of non-scarring hair loss and in these subjects vs normal age-matched controls. Hair loss subjects will have their Northwestern Memorial Hospital and Northwestern Medical Faculty Foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. All subjects will have a 4 mm punch biopsy on the scalp. Tissue PAI-1 levels from scalp skin biopsies will be determined by immunohistochemical staining. Samples will be kept for approximately 15 years, after which time unused samples will be destroyed.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Age-matched control subjects who do not have a history of hair loss * A clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium, alopecia areata or normal scalp skin * All subjects must have given signed, informed consent prior to registration in study

Exclusion criteria

* History of previous hair transplantation * Current and past use of medications topically on the scalp * Clinical or pathologic diagnosis of a scarring alopecia * History of inflammatory conditions of the scalp such as psoriasis

Design outcomes

Primary

Measure	Time frame	Description
PAI-1 expression level in scalp skin biopsy samples	Baseline	Tissue PAI-1 expression levels will be determined by immunohistochemistry, a three-layer biotin-strepavidin system. Positive PAI-1 expression per total tissue area will be quantified using the color-picker function in imaging software.The PAI-1 expression found in normal scalps will be compared to those found in scalps with hair loss.

Countries

United States

Outcome results