Abdominal Aortic Aneurysm
Conditions
Brief summary
The primary aim of this study is to establish the practicality of using two novel imaging modalities for the assessment of biomechanical properties of the aorta.
Detailed description
Patients with Abdominal Aortic Aneurysm, (AAA), will be identified within the vascular surgery practice. Those patients who meet standard indications for surgery including symptomatic AAA, size \>5.0-5.5 cm, or rapidly enlarging \>0.5 cm per 6 months will have standard pre-operative work-up which includes magnetic resonance angiogram (MRA) and Echocardiogram (ECHO). These pre-operative studies will be modified for the study patients to include electrocardiogram(ECG)-gating (coupled with MR angiogram) and 2-Dimensional speckle-tracking ultrasound of the abdominal aorta. Patients in the study will be followed for 1 year. Measurements will be analyzed for any relationship between aortic wall properties and clinical outcomes such as aneurysm growth, rupture risk or aortic dissection. This study will be comparing 3 groups of patients: no surgery (surveillance), open surgery, and endovascular aneurysm repair (EVAR).
Interventions
DEVICEECHO
Imaging
DEVICEECG-gated MRA
Imaging
Sponsors
Mayo Clinic
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \>18 years of age with ability to provide informed consent. * Patients with either symptomatic or asymptomatic AAA as defined by aortic diameter ≥ 1.5x normal diameter. * Patients with non-aneurysmal aortas who require aortic contrast imaging or echocardiography for preoperative planning or other reason.
Exclusion criteria
* Patients with contraindication to IV contrast such as allergy or severe kidney dysfunction. * Patients who do not require contrast imaging or echocardiogram as part of their care plan. * Terminally ill patients, and patients with estimated life expectancy of ≤ 6 months. * Patients unable to tolerate magnetic resonance imaging.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ECHO Imaging | Change from baseline in ECHO imaging measurements | Imaging taken of the aneurysm, locating peak wall stress and measuring percent of strain per seconds. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ECG-gated MRA Imaging | Change from baseline ECG-gated imaging measurements. | The MRA imaging will be taken with the ECG-gating to synchronize the timing of the image acquisition with cardiac motion. This will allow for more accurate measurement of vessel diameter measured in mm (millimeters) and reported in percent change from baseline. |
Countries
United States
Contacts
Primary ContactHoussam Farres, MD
Backup ContactMauricia Buchanan, RN
Outcome results
None listed