Healthy Adults
Conditions
Brief summary
Preliminary data show that high flow nasal air has been shown to reduce promote heat exchange due to evaporation of nasal mucus by the air flow resulting in heat loss. It is unclear whether unidirectional nasal airflow is well tolerated in healthy individuals. The central hypothesis of this proposal is that dry high flow nasal air will be sufficiently tolerated in healthy adults.
Interventions
DEVICENasal High Flow
Sponsors
Johns Hopkins University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women * Able to consent * Age ≥ 18 * BMI\<30kg/m2
Exclusion criteria
* Previous diagnosis of obstructive sleep apnea or sleep disorder * History of Constant Positive Airway Pressure treatment for Obstructive Sleep Apnea * History of recurrent epistasis * Pregnancy (self-report) * Deviated nasal septum * Unstable cardiovascular disease (decompensated Congestive Heart Failure, myocardial infarction or revascularization procedures, unstable arrhythmias) * Uncontrolled hypertension with BP \> 190/110 * Daytime hypoxemia with oxygen saturation\<90% (measured at history and physical examination) * Supplemental oxygen use * Work in transportation industry as a driver or pilot.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Tolerability using Questionnaire | Baseline | Participant response to nasal high flow using 7 point Likert scale |
Countries
United States
Outcome results
None listed